22nd Enzyme Mechanisms Conference
Sunday January 2 - Thursday January 6, 2011
Program Overview
Sunday January 2nd
1:00 - 7:30 pm Conference Check-in (conference desk in hotel lobby)
7:00 - 9:00 pm Opening Reception (sponsored by Biochemistry, celebrating its 50th year of publication)*
Monday January 3rd
7:00 - 10:30 am Conference Check-in (conference desk in hotel lobby)
7:15 - 8:15 am Breakfast*
8.15 - 8:30 am Welcome & Logistics
8:30 am - 12:05 pm Session I: Enzymes as Drug Targets
3:00 - 5:30 pm Poster Session I (Cash Bar)
7:30 - 9:50 pm Session II: New Frontiers in Mechanistic Enzymology
Tuesday January 4th
7:30 - 8:30 am Breakfast*
8:30 am - 12:20 pm Session III: Mechanism of Enzyme Action I
3:00 - 5:30 pm Poster Session II (Cash Bar)
7:30 - 9:50 pm Session IV: Catalytic RNA & Founders Award Lecture
Wednesday January 5th
7:30 - 8:30 am Breakfast*
8:30 am - 12:05 pm Session V: Mechanism of Enzyme Action II
12:15 pm Lunch*
1:30 - 4:15 pm Session VI: Enzymes in Chemical Biology
6:00 - 7:00 pm Cocktails (Cash Bar)*
7:00 pm Closing Banquet*
Thursday January 6th
Check-out and Departure
* Event is included in the Conferee & Guest Registration Fees
Sessions & Speakers
Enzymes as Drug Targets
John Pollard Vertex Pharmaceuticals
Application of Kinetic and Structural Insights for Enzyme-Inhibitor Interactions in Aurora Kinase Drug Discovery
Brion Murray Pfizer Global Research & Development
Enzymatic Analysis of Normal and Oncogenic Receptor Tyrosine Kinase Signaling Impacting Drug Design
George Addona Merck
Impact of Enzymology and Biophysics on Small Molecule Hit Validation and Lead Identification
Richard Magliozzo Brooklyn College CUNY
The Rapid Catalase Activity in the Dual Function Heme Enzyme Catalase-peroxidase (KatG) Requires a Radical on its Novel Met-Tyr-Trp Adduct
David Barondeau Texas A&M University
Human Frataxin is an Allosteric Switch that Activates the Fe-S Cluster Biosynthetic Complex
New Frontiers in Mechanistic Enzymology
Matthew Jacobson University of California, San Francisco
Computational Approaches to Leverage Enzyme Structures to Predict Function
Brian Miller Florida State University
Kinetic Cooperativity in a Monomeric Enzyme
Patsy Babbitt University of California, San Francisco
Privileged Scaffolds, “Underlying” Promiscuity, & Convergence in the Evolution of New Enzyme Functions
Birte Höcker Max Planck Institute for Developmental Biology
Insight into Enzyme Evolution through Protein Engineering Approaches
Mechanism of Enzyme Action I
Vern Schramm Albert Einstein College of Medicine
Dynamic and Thermodynamic Properties of Enzymatic Transition States and Complexes with Transition State Analogues
Ming-Daw Tsai Academia Sinica, Institute of Biological Chemistry
Structural and Mechanistic Bases for the G:G Specificity of ASFV DNA Polymerase X
Andrew Gulick Hauptman-Woodward Institute
Studies of the Domain Interface in Non-ribosomal Peptide Synthetases
Chris Whitman University of Texas at Austin
New Activities from an "Old" Enzyme: The 4-Oxalocrotonate Tautomerase Saga
Po-Huang Liang Academia Sinica, Institute of Biological Chemistry
Kinetic, Mechanistic and Structural Aspects of the cis-Prenyltransferase Catalyzed Lipid Chain Elongation
Catalytic RNA & Founders Award Lecture
Hiroaki Suga University of Tokyo
Genetic Code Reprogramming: Its Concept and Wide Applications
Christopher Murray Sutro Biopharma
Engineering Translation with Non-Natural Aminoacyl-tRNA Libraries
Michael Harris Case Western Reserve University
Analysis of Non-enzymatic and Enzymatic RNA Phosphoryl Transfer Reaction Mechanisms by Kinetic Isotope Effects
Founders Award Lecture: Paul Cook Vanderbilt University
Structure/Function Studies of the Fosfomycin Resistance Enzyme FosB
Mechanism of Enzyme Action II
JoAnne Stubbe Massachusetts Institute of Technology
Unmasking Proton Coupled Electron Transfer in Ribonucleotide Reductases using Unnatural Amino Acids
Sean Elliott Boston University
Thrice Upon a Heme: Redox Reactivities of Bacterial Heme Peroxidases
Danica Fujimori University of California, San Francisco
On the Mechanism of Radical SAM Methyltransferases RlmN and Cfr
Sheryl Tsai University of California, Irvine
Molecular Basis of Polyketide Cyclization
Adrian Keatinge-Clay University of Texas at Austin
How Modular Polyketide Synthase Ketoreductases have Evolved to set Different Combinations of Stereocenters
Enzymes in Chemical Biology
Michael Marletta University of California, Berkeley
Regulation of Histidine Kinases by H-NOX Domains
Minkui Luo Memorial Sloan-Kettering Cancer Center
Engineered Protein Methyltransferases for Bioorthogonal Target Labeling
Hening Lin Cornell University
The Enzymatic Activity of Sirtuins Uncovers Novel Protein Posttranslational Modifications
Kate Carroll Scripps Florida
Painting the Cysteine Chapel: New Tools to Probe Oxidation Biology
Benjamin Cravatt The Scripps Research Institute
Activity-based Proteomics and its Application for Enzyme and Inhibitor Discovery
Organizing Committee
John Richard, Chair SUNY Buffalo
Kay Ahn Pfizer Global Research and Development
Tadhg Begley Texas A&M University
Debra Dunaway-Mariano University of New Mexico
Francine Perler New England Biolabs
Richard Wolfenden University of North Carolina at Chapel Hill
John P. Richard
Tina L. Amyes
University at Buffalo
Department of Chemistry
Buffalo, NY 14260, USA
(716) 645 4232 (John)
(716) 645 4231 (Tina)
Fax: (716) 645 6963