22nd Enzyme Mechanisms Conference
Sunday January 2 - Thursday January 6, 2011
Speakers
The distinguished scientists who will present talks at the conference include:
George Addona Merck
Impact of enzymology and biophysics on small molecule hit validation and lead identification
Patsy Babbitt University of California, San Francisco
Privileged scaffolds, underlying promiscuity & convergence in the evolution of new enzyme reactions
Benjamin Cravatt The Scripps Research Institute
Chemoproteomic strategies for enzyme discovery and characterization
Sean Elliott Boston University
Thrice upon a heme: redox reactivities of bacterial peroxidases
Danica Galonic Fujimori University of California, San Francisco
On the mechanism of methyl transfer by radical SAM methyltransferases RlmN and Cfr
Andrew Gulick Hauptman-Woodward Institute
Studies of the domain interface in non-ribosomal peptide synthetases
Michael Harris Case Western Reserve University
Analysis of enzymatic and non-enzymatic RNA phosphoryl transfer reactions by kinetic isotope effects
Birte Höcker Max Planck Institute for Developmental Biology
Insight into enzyme evolution through protein engineering approaches
Matthew Jacobson University of California, San Francisco
Computational approaches to leverage enzyme structures to predict function
Adrian Keatinge-Clay University of Texas at Austin
How modular polyketide synthase ketoreductases have evolved to set different combinations of stereocenters
Po-Huang Liang Academia Sinica, Genomics Research Center
Kinetic, mechanistic and structural aspects of the cis-prenyltransferase catalyzed lipid chain elongation
Michael Marletta University of California, Berkeley
Regulation of histidine kinases by H-NOX domains
Brian Miller Florida State University
Kinetic cooperativity in a monomeric enzyme
Brion Murray Pfizer Global Research & Development
Enzymatic analysis of normal and oncogenic receptor tyrosine kinase signaling impacting drug design
John Pollard Vertex Pharmaceuticals
Application of kinetic and structural insights for enzyme-inhibitor interactions in Aurora kinase drug discovery
Vern Schramm Albert Einstein College of Medicine
Transition states, analogues and mechanism from isotope effects
JoAnne Stubbe Massachusetts Institute of Technology
Dimanganese ribonucleotide reductases: assembly in vitro and in vivo
Hiroaki Suga University of Tokyo
Genetic code reprogramming: Its concept and wide applications
Ming-Daw Tsai Academia Sinica, Institute of Biological Chemistry
Structural and mechanistic bases for the G:G specificity of ASFV DNA polymerase X
Sheryl Tsai University of California, Irvine
Molecular origami in nature: The cyclization specificity of polyketide natural products
Chris Whitman University of Texas at Austin
New activities from an "old" enzyme: The 4-oxalocrotonate tautomerase saga
Organizing Committee
John Richard, Chair SUNY Buffalo
Kay Ahn Pfizer Global Research and Development
Tadhg Begley Texas A&M University
Debra Dunaway-Mariano University of New Mexico
Francine Perler New England Biolabs
Richard Wolfenden University of North Carolina at Chapel Hill
John P. Richard (Conference Organizer)
Tina L. Amyes (Conference Administrator)
University at Buffalo
Department of Chemistry
Buffalo, NY 14260, USA
(716) 645 4232 (John)
(716) 645 4231 (Tina)
Fax: (716) 645 6963