Sunday, January 6


7:00 – 9:00 pm                        Reception:  Laissez les bon temps rouler!


Monday, January 7


7:30-8:30                                 Breakfast


8:25                                         Welcome


Session 1 – From the active site to the bedside

Chair: Richard Silverman, Northwestern


8:30     Chaitan Khosla – Stanford

“An allosteric disulfide bond and its role in celiac disease pathogenesis”

9:05     Tom Meek – Texas A & M

“2 Infectious diseases, 2 enzymes, and maybe 2 lead compounds”

9:40     Vern Schramm – Albert Einstein College of Medicine

“Transition state analogues for ribosyl transferases”

10:15-10:45                             Coffee break


Session 2 – Promiscuity and enzymes – what happens in the active site stays there?  

Chair: John Richard, SUNY Buffalo


10:45   Shelley Copley – University of Colorado Boulder

            “Bumps in the road toward evolution of a new enzyme”

11:20   Chris Whitman – UT Austin

“Analysis of the fused 4-oxocrotonate tautomerases:  Implications for divergence in the tautomerase superfamily”

11:55   John Gerlt – UIUC

“Genomic enzymology: Discovery of novel enzymes and metabolic pathways”

12:30                                       Lunch (not provided)


3:00 – 5:00 pm                        Poster Session I (Odd numbered posters, cash bar)

Session 3 – The holy trinity – Enzymes, Coenzymes, and Metabolic Pathways

Chair: Squire Booker, Penn State University


7:00     Elizabeth Sattely – Stanford

“Discovery and engineering of plant chemistry for plant and human health”

7:35     Mo Seyedsayamdost– Princeton

“New metalloenzyme-catalyzed transformations in natural product biosynthesis”

8:10     Tadhg Begley– Texas A&M University

“Mechanistic studies on the futalosine-dependent menaquinone biosynthetic pathway”

8:45     Wulf Blankenfeldt – Helmholtz Centre for Infection Research

Poster talk: “The alkylquinolone repertoire of Pseudomonas aeruginosais linked to structural flexibility of the FabH-like Pseudomonas quinolone signal biosynthesis enzyme PqsBC”


Tuesday, January 8


7:30-8:30                                 Breakfast


Session 4 – A biosynthetic menagerie

Chair: Karen Allen, Boston University

8:30     Janet Smith – University of Michigan

“Deciphering the activities of natural product biosynthetic enzymes: Not all domains are what they appear to be”

9:05     Yi Tang – UCLA

“Discovery and characterization of a SAM-dependent pericyclase”

9:40     Amy Rosenzweig – Northwestern

“Biosynthesis of methanobactin”

10:15-10:45                             Coffee Break


Session 5 – Picking on the bass

Chair: Ken Johnson, UT Austin


10:45   Craig Cameron – Penn State

“Targeting a viral polymerase for antiviral therapy: Insight from studies of single molecules and single, infected cells”

11:20   Peter Weigele – New England BioLabs

“Pathways of thymidine hypermodification”

11:55   Jane Jackman – Ohio State

“A new direction for RNA polymerases: 3’-5’ polymerase mechanism and function”


12:30                                       Lunch (not provided)


3:00 – 5:00 pm                        Poster Session II (Even numbered posters, cash bar)


Session 6 – A good drug is hard to find

Chair: Elham Behshad, Incyte


7:00     Alan Rendina – GSK

“Uncovering novel Inhibitor sites and mechanisms takes both screening and sleuthing – Tales from the big pharma trenches”

7:35     John Quinn– Genentech

“Real-time, label-free measurement of inhibitor affinity and kinetics”

8:10     Karen Maegley– Pfizer

“Targeting protein arginine methyltransferase 5 (PRMT5) for cancer therapy; development of a SAM competitive inhibitor with potent antitumor activity and a decrease liability for developing resistance”


8:45     Norbert Reich– UC Santa Barbara

Poster talk: “DNMT3A mutations in AML patients cause loss and gain of function and differential regulation by protein partners”


Wednesday, January 9


7:30-8:30                                 Breakfast


Session 7 – Sugar Bowl!

Chair: Frank Raushel, Texas A&M


8:30     Hazel Holden – UW Madison

“N-Formylated sugars – are they the kiss of death?”


9:05     Stephen Withers – UBC

“Discovery of CAZymes for cell surface glycan removal through metagenomics: Towards universal blood”


9:40     Jianyong Jiang– UW Madison

            Poster talk: “Specificity, function and regulation of protein O-GlcNAc modification”


9:55     Liz Hedstrom – Brandeis

Poster talk: “Dynamic characteristics of GMP reductase complexes revealed by high resolution 31P field cycling NMR relaxometry”



10:15-10:45                             Coffee Break


Session 8 – When metal ions and electrons go marching in! 

Chair: Aimin Liu, UTSA


10:45   Stephen Ragsdale – University of Michigan

“Coupling of electron transfer and chemical reactions to drive organometallic and radical-based enzymatic catalysis by nickel enzymes”

11:20   Marty Bollinger – Penn State University

“How iron- and 2-(oxo)glutarate-dependent oxygenases direct their common ferryl intermediate to different outcomes”


11:55   Sean Elliott – Boston University

“Radical SAM enzymes, viewed through an electrochemical lens”


12:30-1:30                               Lunch buffet



2:00     Founders Award lecture: Melanie Higgins – UBC

“Characterization of a heme-dependent N-N bond forming enzyme”




Session 9 – Farewell to the Big Easy with a biosynthetic tryptich

Chair: Gene Cordes


2:30     Wilfred van der Donk – UIUC and HHMI

“Posttranslational modifications during cyclic peptide biosynthesis”


3:05     Judith Klinman– UC Berkeley

“PQQ biosynthesis: Getting close to the finish line”


3:40     Dale Poulter– University of Utah

“Isopentenyl diphosphate isomerase.  Breaking up is hard to do”


6:00     Closing banquet:  Second line

            Cocktails and hors d’oeuvres, dinner at 7 pm