Wednesday, January 3

6:00-8:00 pm   Opening Reception - Mangrove Pool

 

Thursday, January 4

7:00-8:30 am   Breakfast ‒ Royal Palm 6-8

 

Session 1 ‒ Spoonbill ‒ Royal Palm 4-5                       

Chair ‒ TBA

 

8:00-8:10      Welcome

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8:10-8:40       Pimchai Chaiyen - Mechanistic investigation and engineering of flavin-dependent enzymes

                

8:40-9:10       Dennis Murphy - Stereochemical discrimination of a covalent, irreversible werner helicase inhibitor                                        series     

                     

9:10-9:40      Alexey Silakov - Understanding why some [FeFe] hydrogenases tolerate the presence of oxygen

            

9:40-10:00   Three Three-minute Poster Pitches

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Poster Session 1

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10:00-12:00   Coffee Break/Poster Session - Royal Palm 1-3

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12:00-1:00pm Lunch - Royal Palm 6-8

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Session 2 ‒ Alligator ‒ Royal Palm 4-5

Chair ‒ TBA

 

1:00-1:30    Aimin Liu - Protein-derived cofactor in bifunctional enzyme KatG from M. tuberculosis: It takes two to                                     tango

                

1:30-2:00     Adrian Keatinge Clay - Engineering polyketide synthases using the correct module boundary

                

2:00-2:30     Suzanne Walker - How bacteria acylate their cell envelopes to protect themselves from antibiotics

                

3:00-7:00     Free Time/Dinner (not provided)

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4:00-5:00 Industry Career Workshop with David Olsen (Merck) - Pharmaceutical Industry Job Hunting: Distinguishing Yourself from the Crowd

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Session 3 ‒ Mangrove  ‒ Royal Palm 4-5

Chair ‒ TBA

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7:00-7:30    Nozomi Ando - Structural dynamics of complex metalloenzymes    

                

7:30-8:00    Frederick Stull  - Exceptions to the oxidase paradigm of the flavoprotein amine oxidase superfamily 

                 

8:00-8:30    Reuben Peters - TerDockin: Stuffing carbocations into terpene synthases to refine catalytic activity

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8:30-8:50    Three Three-minute Poster Pitches

              

Poster Session 2

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8:50-10:00   Drinks/Poster Session - Royal Palm 1-3, Royal Palm Foyer

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Friday, January 5

7:00-8:30 am   Breakfast ‒ Royal Palm 6-8

 

Session 4 ‒ Bottlenose ‒ Royal Palm 4-5                       

Chair ‒ TBA

 

8:00-8:10      Welcome/Announcements

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8:10-8:40      Lana Saleh - 5-Methylpyrimidine dioxygenases (5mYOXs) and their partner proteins in base modification

                

8:40-9:10      Robin Teufel - Flavoenzyme-catalyzed redox tailoring of bacterial tropone natural products

                     

9:10-9:40      Oscar Juarez - The electron transfer and ion pumping mechanisms of the evolutionary divergent NQR                                    family

            

9:40-10:00    Three Three-minute Poster Pitches

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Poster Session 3

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10:00-12:00   Coffee Break/Poster Session - Royal Palm 1-3, Royal Palm Foyer

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12:00-1:00pm Lunch - Royal Palm 6-8

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Session 5 ‒ Manatee ‒ Royal Palm 4-5 

Chair ‒ TBA

 

1:00-1:30     Andy Gulick  - Structural and mechanistic studies of enzymes involved in siderophore biosynthesis

                

1:30-2:00     Diane Retallack - Discovery and development of enzyme therapeutics using the advanced Pseudomonas                              fluorescens-based protein expression platform

                

2:00-2:30     Leslie Poole - Structural and dynamic features of peroxiredoxins aligned with their roles in peroxide                                       defense and signaling      

                

3:00-7:00     Free Time/Dinner (not provided)

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Session 6 ‒ Heron  ‒ Royal Palm 4-5

Chair ‒ TBA

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7:00-7:30    Wilfred van der Donk - Genome Mining for New Enzymology       

                

7:30-8:00    David Olsen  - Malaria aspartyl protease inhibitors:  From an unknown mechanism of action screening                                 hit to dual-targeting of essential enzymes

                 

8:00-8:30    Founders Award - TBA

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8:30-8:50    Three Three-minute Poster Pitches

              

Poster Session 4

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8:50-10:00   Drinks/Poster Session - Royal Palm 1-3, Royal Palm Foyer

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Saturday, January 6

7:00-8:30 am   Breakfast ‒ Royal Palm 6-8

 

Session 7 ‒ Otter ‒ Royal Palm 4-5                       

Chair ‒ TBA

 

8:00-8:10      Welcome/Announcements

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8:10-8:40       Robert Hausinger - Biosynthesis and functions of the nickel-pincer nucleotide cofactor

                

8:40-9:10       Erik Ralph - Targeting Glycogen Synthase I for the treatment of glycogen storage diseases

                     

9:10-9:40       Katherine Davis - Examining the structural basis for atypical heme enzyme reactivity

            

9:40-10:10     Brian Miller - Evolutionary origins of vertebrate glucose homeostatic regulation

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10:10-10:30   Coffee Break - Royal Palm Foyer

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Session 8 ‒ Egret ‒ Royal Palm 4-5                       

Chair ‒ TBA

 

10:30-11:00     Rafael Guimaraes da Silva  - Structure and mechanism of a nucleotide sanitizing enzyme with a role                                       in cancer

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11:00-11:30      Neil Marsh - Prenylated-flavin dependent decarboxylases

                

11:30-12:00      Dean Brown - Discovery and characterization of JNT-517, an inhibitor of SLC6A19 for the treatment of                                    phenylketonuria

                     

12:00-12:30      Michelle Chang  - Synthetic biology approaches to new chemistry

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12:30-2:00pm  Lunch - Royal Palm 6-8

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Session 9 ‒ Hibiscus ‒ Royal Palm 4-5

Chair ‒ TBA

 

2:00-2:30      Samer Gozem - Bringing together quantum mechanics, molecular dynamics, and experiments to                                            study flavoproteins

                

2:30-3:00      Sharon Hammes-Schiffer - Proton-Coupled Electron Transfer in Enzymes

                

3:00-3:30      Jack Tanner - Mechanism-based covalent inactivation of the flavoenzyme proline dehydrogenase

                

3:30-4:00.     Joan Broderick  - Delineating Mechanistic Steps in Radical SAM Reactions

 

4:00-6:00       Free Time

 

Closing Banquet

6:00-7:00 pm   Reception with hors-d’oeuvres - Vista Terrace

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7:00                    Banquet – On the beach

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Sunday, January 7

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AM depart conference

 

Funding provided by the Sponsors of EMC2024 was not used for the benefit of specific individuals. The program of EMC2024 was not influenced in any way by the Sponsors. Sponsor funds did not result in any transfer of value to physicians or other attendees. Sponsors do not endorse any views presented at EMC2024.