Wednesday, January 3

6:00-8:00 pm   

Opening Reception - Mangrove Pool

 

Thursday, January 4

7:00-8:30 am   

Breakfast ‒ Royal Palm 6-8

 

Session 1 ‒ Spoonbill ‒ Royal Palm 4-5

Chair ‒ Marcus Hartmann (Max Planck Institute for Biology)

 

8:00-8:10 am

Welcome

​

8:10-8:40 am

Nozomi Ando (Cornell U) - Conformational Ensembles of Flexible Multi-Domain Enzymes

                

 8:40-9:10 am

Dennis Murphy (GSK) - Stereochemical discrimination of a covalent, irreversible werner helicase inhibitor series     

                     

9:10-9:40 am

Alexey Silakov (Penn State U) - Understanding why some [FeFe] hydrogenases tolerate the presence of oxygen

            

9:40-10:00 am

Three Three-minute Poster Pitches

1. Anna Zmich - Structural and mechanistic exploration of a thermostable Cystathionine γ-lyase reveals a new catalytic function

2. Madison Smith - Thioredoxin glutathione reductase (TGR): Transient State Characterization of a Complex Flavin Disulfide Reductase

3. Antonio Del Rio Flores - De novo biosynthesis of azide by a promiscuous N-nitrosylase

​

Poster Session 1

​

10:00 am-12:00 pm

Coffee Break/Poster Session - Royal Palm 1-3

​

12:00-1:00 pm

Lunch - Royal Palm 6-8

​

Session 2 ‒ Alligator ‒ Royal Palm 4-5

Chair ‒ Dhara Shah  (Arizona State U)

 

1:00-1:30 pm

Aimin Liu (UT San Antonio) - Bringing Amino Acids Together: Unlocking New Chemical Potential

                

1:30-2:00 pm

Adrian Keatinge Clay (UT Austin) - Engineering polyketide synthases using the correct module boundary

                

2:00-2:30 pm

Suzanne Walker (Harvard U) - How bacteria acylate their cell envelopes to protect themselves from antibiotics

                

3:00-7:00 pm

Free Time/Dinner (not provided)

​

4:00-5:00 Industry Career Workshop with David Olsen (Merck) - Pharmaceutical Industry Job Hunting:       Distinguishing Yourself from the Crowd

​

Session 3 ‒ Mangrove  ‒ Royal Palm 4-5

Chair ‒ Edwin Antony (St Louis University)

​

7:00-7:30 pm

Erika Taylor (Wesleyan U) - Rethinking the Aminoglycosides Mechanism of Action: Evidence for Inhibition of Heptosyltransferase I from Escherichia coli

                

7:30-8:00 pm

Frederick Stull (Western Michigan U) - Exceptions to the oxidase paradigm of the flavoprotein amine oxidase superfamily 

                 

8:00-8:30 pm

Reuben Peters (Iowa State U) - TerDockin: Stuffing carbocations into terpene synthases to refine catalytic activity

​

8:30-8:50 pm

Three Three-minute Poster Pitches

1. Zoe Hoffpauir - The riboflavinator: A new hope

2. Yu Yue - Peptide extension after chain reversal during non-ribosomal peptide biosynthesis

3.  Mark Schmidt-Dannert - Terpene synthases

​

Poster Session 2

​

8:50-10:00 pm   

Drinks/Poster Session - Royal Palm 1-3, Royal Palm Foyer

​

Friday, January 5

7:00-8:30 am

Breakfast ‒ Royal Palm 6-8

 

Session 4 ‒ Bottlenose ‒ Royal Palm 4-5

Chair ‒ Jeff McFarlane (Fort Lewis College)

 

8:00-8:10 am

Welcome/Announcements

​

8:10-8:40 am

Lana Saleh (New England Biolabs) - 5-Methylpyrimidine dioxygenases (5mYOXs) and their partner proteins in base modification

                

8:40-9:10 am

Robin Teufel (U Basel) - Flavoenzyme-catalyzed redox tailoring of bacterial tropone natural products

                     

9:10-9:40 am

Oscar Juarez (IIT) - The electron transfer and ion pumping mechanisms of the evolutionary divergent NQR family

            

9:40-10:00 am

Three Three-minute Poster Pitches

 1. Jake Lachowicz - Structural and Mechanistic Determinants of ddhNTP Catalysis by the Ancient Antiviral Enzyme, Viperin

2. Josseline Ramos - Figueroa - Uncovering the biosynthetic pathway towards the production of Ammosamide 

3. Monica MacDonald - Mutagenesis as a Strategy for Pyrrolobenzodiazepines Biochemical Synthesis

​

Poster Session 3

​

10:00 am-12:00 pm

Coffee Break/Poster Session - Royal Palm 1-3, Royal Palm Foyer

​

12:00-1:00pm

Lunch - Royal Palm 6-8

​

Session 5 ‒ Manatee ‒ Royal Palm 4-5

Chair ‒ Holly Ellis (East Carolina U)

 

1:00-1:30 pm

Andy Gulick (U at Buffalo)  - Structural and Mechanistic Studies of Enzymes Involved in NRPS-Independent Siderophore Biosynthesis

                

1:30-2:00 pm

Diane Retallack (Primrose Bio) - Discovery and development of enzyme therapeutics using the advanced Pseudomonas fluorescens-based protein expression platform

                

2:00-2:30 pm

Michelle Chang (UC Berkeley)  - Synthetic biology approaches to new chemistry

                

3:00-5:30 pm

Free Time

5:30-7:00 pm

Dinner ‒ Royal Palm 6-8

​

Session 6 ‒ Heron  ‒ Royal Palm 4-5

Chair ‒ Catherine Goodman (ACS Journals)

​

7:00-7:30 pm

Wilfred van der Donk (U Illinois) - Genome Mining for New Enzymology       

                

7:30-8:00 pm

David Olsen (Merck)  - Malaria aspartyl protease inhibitors:  From an unknown mechanism of action screening hit to dual-targeting of essential enzymes

                 

8:00-8:30 pm

Founders Award Lecture

 Leo Betancurt (Pastuer Institute/NEB) -Proofreading mechanism for family D DNA polymerases

​

8:30-8:50 pm

Three Three-minute Poster Pitches

1. Elijah Kissman - A dynamic metal coordination sphere controls chemoselectivity in radical amino acid halogenases

2. Javeria Akram - Characterization of oxidant specificity in bacterial flavoprotein amine "oxidases"

3. Mercedes Fisk - A rare NRPS-NIS hybrid for the biosynthesis of the siderphore Norcardichelin

           

Poster Session 4

​

8:50-10:00 pm

Drinks/Poster Session - Royal Palm 1-3, Royal Palm Foyer

​

Saturday, January 6

7:00-8:30 am

Breakfast ‒ Royal Palm 6-8

 

Session 7 ‒ Otter ‒ Royal Palm 4-5

Chair ‒  Jeremy Lohman (Michigan State U)

 

8:30-8:40 am

Welcome/Announcements

                

8:40-9:10 am

Erik Ralph (Pfizer) - Targeting Glycogen Synthase I for the treatment of glycogen storage diseases

                     

9:10-9:40 am

Katherine Davis (Emory U) - Examining the structural basis for atypical heme enzyme reactivity

            

9:40-10:10 am

Brian Miller (Florida State U)- Evolutionary origins of vertebrate glucose homeostatic regulation

​

10:10-10:30 am

Coffee Break - Royal Palm Foyer

​

Session 8 ‒ Egret ‒ Royal Palm 4-5

Chair ‒ Mark Snider (College of Wooster)

 

10:30-11:00 am

Rafael Guimaraes da Silva (U St. Andrews)  - Structure and mechanism of a nucleotide sanitizing enzyme with a role in cancer

​

11:00-11:30 am

Neil Marsh (U Michigan) - Prenylated-flavin dependent decarboxylases

                

11:30 am-12:00 pm

Dean Brown (Jnana Therapeutics) - Discovery and characterization of JNT-517, an inhibitor of SLC6A19 for the treatment of phenylketonuria

                     

12:00-12:30 pm

Leslie Poole (Wake Forest U) - Structural and dynamic features of peroxiredoxins aligned with their roles in peroxide defense and signaling

​

12:30-2:00 pm

Lunch - Royal Palm 6-8

​

Session 9 ‒ Hibiscus ‒ Royal Palm 4-5

Chair ‒ Andrew Murkin (University at Buffalo)

 

2:00-2:30 pm

Samer Gozem (Georgia State U) - Bringing together quantum mechanics, molecular dynamics, and experiments to study flavoproteins

                

2:30-3:00 pm

Sharon Hammes-Schiffer (Princeton U)- Proton-Coupled Electron Transfer in Enzymes

                

3:00-3:30 pm

Jack Tanner (U of Missouri) - Mechanism-based covalent inactivation of the flavoenzyme proline dehydrogenase

                

3:30-4:00 pm 

Joan Broderick (Montana State U)  - Delineating Mechanistic Steps in Radical SAM Reactions

​

4:00-4:10

Awards Presentation

4:10-6:00

Free Time

​

Closing Banquet

6:00-7:00 pm

Reception with hors-d’oeuvres - Sunset Veranda

​

7:00 pm

Banquet –Mangrove Pool

​

Sunday, January 7

​

AM depart conference

 

Funding provided by the Sponsors of EMC2024 was not used for the benefit of specific individuals. The program of EMC2024 was not influenced in any way by the Sponsors. Sponsor funds did not result in any transfer of value to physicians or other attendees. Sponsors do not endorse any views presented at EMC2024.