Sunday, January 4

2:30-5:30 pm

REGISTRATION

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6:00-8:00 pm   

Opening Reception - Luna Lawn

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Monday, January 5

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Session 1 ‒  Luna Ballroom

Enzymes and Health

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8:30-8:45 am

Welcome

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8:45-9:15 am

Luiz Pedro Carvalho (UF Scripps Institute) - Deconstructing Allosteric Inhibition of MAT2A: Towards Resistance-Proof Anti-Cancer Molecule 

                

 9:15-9:45 am

Christina M. Woo (Harvard) - Post-Translational Regulation of Glutamine Aynthetase through Enzymes and E3 Ligases      

                     

9:45-10:15 am

Qingan Sun (Bayer Crop Science) - Selective Inhibition of Fungal IMPDH by a Novel Macrocyclic Peptide Targeting a Non-Canonical Allosteric Site

            

10:15-10:45 am

Coffee Break

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Session 2 ‒ Luna Ballroom

Natural Products I

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10:45-11:15 am

Kou-San Ju (The Ohio State University) - Biosynthetic Diversification of Phosphonopeptide Natural Products

                

11:15-11:45 am

Bradley S. Moore (Scripps Institute of Oceanography) - Enzyme Discovery from the Seashore to the Deep Ocean

                

11:45-12:15 pm

Louise K. Charkoudian (Haverford College) - Exploring the Inner Workings of Type II Polyketide Synthases for Expanded Access to Biosynthetic Products

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12:15-12:45 pm

Trainee Flash Talks I 

                

12:45-2:00 pm

Lunch

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2:00-4:00 Poster Session, Luna Ballroom

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Session 3 Luna Ballroom

Enzymology I 

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4:00-4:30 pm

Graham R. Moran (Loyola University) - A Descriptive Analysis of Transient-state Observations for Thioredoxin Glutathione Reductase from Schistosoma mansoni

                

4:30-5:00 pm

Wen Zhu (Florida State University) - Dissecting the Conformational Assembly of Human Asparagine Synthetase 

                 

5:00-5:30 pm

Patrick A. Frantom (University of Alabama)  - Mechanisms of Protected Persulfide Transfer in the Suf Pathway for Bacterial Fe-S Cluster Assembly

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5:30 pm

Trainee Flash Talks II

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7:30-9:00 pm   

Posters and Social Session - Luna Lawn

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Tuesday, January 6

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Session 4 ‒ Luna Ballroom 

Natural Products II

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8:30-9:00 am

T. Martin Schmeing (McGill University) - Megaenzyme Mechanisms

                

9:00-9:30 am

Michael D. Burkart (UCSD) - High-Resolution Cryo-EM of Crosslinked NRPS ande PKS Megasynthetase Assembly Lines

                     

9:00-10:00 am

Alison Butler (UCSB) - Siderophores in Stereo: Chirality in Microbial Iron Acquisition

            

10:00-10:30 am

Coffee Break

 

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Session 5 ‒ Luna Ballroom

Enzymology II

 

10:30-11:00 am

Audrey L. Lamb (UTSA)  - How to Make Riboflavin (in At Least Nine Complicated Enzymatic Steps)

                

11:00 - 11:30 am

Robert P. Hausinger (Michigan State) - Biosynthesis and Utilization of Nickel-Pincer Nucleotide Cofactors

                

11:30-12:00 pm

Pablo Sobrado (Missouri University of Science and Technology)  - Hydroxylation of Amines by Flavin-Dependent Enzymes

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12:00-12:30 pm

John Richard (University at Buffalo)  - Substrate-Driven Protein Conformational Changes in Catalysis by Nature’s Most Proficient Enzymes

                

12:30-2:00 pm

Lunch

2:00-4:00 Poster Session, Luna Ballroom

 

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Session 6 ‒ Luna Ballroom

Biosynthesis

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4:00-4:30 pm

Elizabeth Sattely (Stanford and HHMI) - Chemistry and Biology of Taxol Biosynthesis       

                

4:30-5:00 pm

Joseph M. Jez (Washington University)  - Molecular Controls in Plan Hormone Signaling 

                 

5:00-5:30 pm

Lona M. Alkhalaf (University of Warwick) - Structural Basis for [1,3]-Phosphate Shift in Bacterial Hormone Biosynthesis

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5:30-6:00 pm

Founders' Award Talk and Award Presentation

Kristin Osika (University of Pennsylvania) -  Structural Snapshots of Catalysis in a Bifunctional Terpene Cyclase

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7:30-9:00 pm   

Posters and Social Session - Luna Lawn

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Wednesday, January 7

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Session 7 ‒ Luna Ballroom 

Chemical Biology 

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8:00-9:00 am

Benjamin F. Cravatt (The Scripps Research Institute) - Activity-Based Protein Profiling – Target and Ligand Discovery on a Global Scale 

                     

9:00-9:30 am

Chihui An (Merck & Co., Inc) - Biocatalytic Synthesis of Non-Natural Peptides

            

9:30-10:00 am

Dhara D. Shah (Arizona State U) - A Sulfotransferase from a Gut Microbe Acts on Diverse Phenolic Sulfate Compounds, Including Acetaminophen Sulfate

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10:00-10:30 am

Coffee Break

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Session 8 - Luna Ballroom 

Metalloenzymology

 

10:30-11:00 am

Amie K. Boal (Penn State U)  - The Periodic Table of Ribonucleotide Reducatases

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11:00-11:30 am

Katherine S. Ryan (U of British Columbia) - Heme-dependent Enzymes in Nitrogen-Nitrogen Bond-Formation

                

11:30 am-12:00 pm

Catherine L. Drennan (MIT and HHMI) - The Hard Work of Making Deoxyribonucleotides

                     

12:00-12:30 pm

Squire J. Booker (U Penn) - Structure, Mechanism, and Annotation of Cobalamin-Dependent Radical SAM

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12:30-2:00 pm

Lunch

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Session 9 ‒ Luna Ballroom 

Protein Engineering

 

3:00-3:30 pm

Yang Yang (UCSB) - Design and Development of New Radical Enzymolog 

                

3:30-4:00 pm

Kelly M. Zatopek (New England Biolabs) A NUDIX Jack-of-all-Trades: Structural and Functional Analysis of Archaeal Nudα

                

4:00-4:30 pm

Allison S. Walker (Vanderbilt U) - Artificial Intelligence for Genome Mining and Engineering Biosynthesis

                

4:30 pm 

Closing Announcements  Tim Wencewicz and Andrew Gulick ​

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Closing Banquet

6:00-7:00 pm

Reception with hors-d’oeuvres - Luna Lawn

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7:00 pm

Banquet - Luna Lawn

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Thursday, January 8

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AM Depart conference

 

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Funding provided by the Sponsors of EMC2026 was not used for the benefit of specific individuals. The program of EMC2026 was not influenced in any way by the Sponsors. Sponsor funds did not result in any transfer of value to physicians or other attendees. Sponsors do not endorse any views presented at EMC2026.